The use of ELISA in pemphigus
نویسنده
چکیده
Pemphigus is a group of autoimmune blistering diseases. There had been abundant evidence that antibodies against components within the desmosomes were responsible for its pathogenesis. The major antigens in pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 (130 kDa) and desmoglein 1 (160 kDa) respectively. They are glycoproteins belonging to the cadherin family and form part of the transmembranous component of the desmosomes.1 Conventionally, pemphigus vulgaris and pemphigus foliaceus are distinguished by their differences in clinical and histological features.
منابع مشابه
Development of an ELISA Based Method for the Detection of Pemphigus vulgaris Autoantibodies
For the evaluation of autoantibodies in Pemphigus vulgaris (PV), an indirect ELISA assay was developed by using a semi-purified human epidermal skin extracted with approximately a molecular weight (M.W.) of 130-160 kDa. The evaluation of Pemphigus IgG, IgM and IgA autoantibodies in 75 patients and 50 control sera indicated that this indirect ELISA assay was a useful method for the detection of ...
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